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Antisauvagine-30
Catalog Number: orb1679261
| Catalog Number | orb1679261 |
|---|---|
| Category | Small Molecules |
| Description | Antisauvagine-30 |
| CAS Number | 220673-95-0 |
| Purity | 98% |
| MW | 3650.29 |
| Formula | C161H274N48O46S |
| Biological Activity | Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
