Anti-LAG3 / CD223 Reference Antibody (relatlimab)

• Catalog Number: orb1818458
• Category: Antibodies
• Description: Recombinant Antibody
• Clonality: Monoclonal
• Tested applications: ELISA, FC
• Reactivity: Human, Monkey
• Isotype: IgG4SP
• Antibody Type: Primary Antibody
• Concentration: 1mg/ml
• Form/Appearance: Purified monoclonal antibody supplied in PBS, pH 6.0, without preservative.This antibody is purified through a protein A column.
• Conjugation: Unconjugated
• MW: 145.58
• UniProt ID: P18627
• Protein Sequence: LAG3 / CD223
• Expression System: CHO Cell
• Endotoxins: < 0.001EU/μg,determined by LAL method.
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Alternative names: Lymphocyte activation gene 3 protein, LAG-3, CD223
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

The purity of Anti-LAG3 / CD223 Reference Antibody (relatlimab) is more than 100%, determined by SEC-HPLC.

Immobilized human LAG3 His at 2 µg/mL can bind Anti-LAG3 / CD223 Reference Antibody (relatlimab), EC50=0.02812 µg/mL.

Anti-LAG3 / CD223 Reference Antibody (relatlimab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%

Relatlimab inhibited the tumor growth of MC38 on Human LAG3 mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 53.8% at 10 mpk at D28.

Human LAG3 CHO cells were stained with Anti-LAG3 / CD223 Reference Antibody (relatlimab) and negative control protein respectively, washed and then followed by PE and analyzed with FACS, EC78=0.5464 ug/mL