Amino-PEG12-acid

SKU: orb1307564

Description

Amino-PEG12-acid is a flexible, water-soluble linker used in the synthesis of PROTACs and other bifunctional molecules. Its extended PEG spacer is valuable for constructing degraders in cancer and disease research, facilitating both in vitro biochemical assays and in vivo proof-of-concept studies due to its improved pharmacokinetic properties.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1415408-69-3
• MW: 617.724
• Purity: 98.61% (May vary between batches)
• Formula: C₂₇H₅₅NO₁₄
• SMILES: NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs consist of two ligands joined by a linker: one ligand targets an E3 ubiquitin ligase, and the other targets the specific protein. These compounds harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PEGs, PROTAC Linkers, PROTAC Linker, PROTACLinker, AminoPEG12acid, Amino-PEG-12-acid, Amino-PEG12-acid, Amino PEG12 acid, Inhibitor, inhibit

Compound Identifiers

PubChem CID

53433573