Afobazol HCl

• Catalog Number: orb757684
• Category: Small Molecules
• Description: Afobazole is a multi-targeted anxiolytic drug with neuroprotective activities. It binds to the sigma-1, melatonin MT1, and MT3 receptors, as well as monoamine oxidase A (MAO-A, Kis = 5.9, 160, 0.97, and 3.6 μM, respectively, in a radioligand binding assay). Afobazole (5 mg/kg) decreases the latency to enter, as well as increases the number of entries into and percentage of time spent in, the open arms of the elevated plus maze, indicating anxiolytic-like activity in passive stress-coping BALB/c, but not active stress-coping C57BL/6, mice. It decreases stroke volume and neuronal and oligodendroglial cell death in the brain in a rat model of ischemia induced by middle cerebral artery occlusion (MCAO) when administered at doses of 0.3 and 3 mg/kg.
• CAS Number: [173352-39-1]
• MW: 343.87
• SMILES: CCOC1=CC=C2NC(SCCN3CCOCC3)=NC2=C1.[H]Cl
• Formula: C₁₅H₂₂ClN₃O₂S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.