Afegostat TFA

• Catalog Number: orb1738004
• Category: Small Molecules
• Description: Afegostat TFA
• Purity: 98.00%
• MW: 261.2
• Biological Activity: Afegostat, aslo known as Isofagomine, and AT2101, was an experimental drug for the treatment of certain forms of Gaucher's disease. Isofagomine (IFG) is an acid β-glucosidase (GCase) active site inhibitor that acts as a pharmacological chaperone. FG inhibits GCase with K(i) ~30 nM for wild-type and mutant enzymes (N370S and V394L). Administration of IFG (30 mg/kg/day) to the mice homozygous for GCase mutations (V394L, D409H, or D409V) led to increased GCase activity in visceral tissues and brain extracts.
• CAS Number: 1084896-50-3
• Formula: C₈H₁₄F₃NO₅
• SMILES: C(C(O)=O)(F)(F)F.C(O)[C@@H]1[C@@H](O)[C@H](O)CNC1
• Storage: -20°C
• Note: For research use only