AD4

SKU: orb2278394

Description

AD4 is a potent artemisinin-based PROTAC that induces targeted degradation of PCLAF with an IC50 of 0.6 nM in RS4;11 cells. This action activates the p21/Rb pathway, demonstrating antitumor effects in vitro and extending survival in a mouse xenograft model, supporting its study in oncology and targeted protein degradation research.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2918262-09-4
• MW: 1035.23
• Formula: C₅₅H₇₈N₄O₁₅
• SMILES: C[C@@H]1[C@]2([C@]34[C@@](O[C@](C)(OO3)CC[C@]4([C@H](C)CC2)[H])(O[C@@H]1OCCN(CCO[C@H]5O[C@]6([C@]78[C@]([C@H]5C)(CC[C@@H](C)[C@@]7(CC[C@](C)(O6)OO8)[H])[H])[H])C(CCCCCCCNC9=C%10C(C(=O)N(C%10=O)C%11C(=O)NC(=O)CC%11)=CC=C9)=O)[H])[H]
• Target: Others,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171370424