Acetohexamide

SKU: orb1310266

Description

Acetohexamide is a first-generation sulfonylurea antidiabetic agent that acts by inhibiting the SUR1/KIR6.2 pancreatic KATP channel. It is metabolized to its active form, hydroxyhexamide, and is used in research to study insulin secretion mechanisms and diabetes pathophysiology in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 968-81-0
• MW: 324.40
• Purity: 99.85% (May vary between batches)
• Formula: C₁₅H₂₀N₂O₄S
• SMILES: CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
• Target: Others,Potassium Channel,NADPH
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (6.17 mM);DMSO:30 mg/mL (92.48 mM)

Bioactivity

• Target IC50:
  SUR1:22.9 µM(Ki)|KIR6.2:14.2 µM(Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Acetohexamid, Acetohexamide, Dymelor, Inhibitor, Gamadiabet, inhibit, NADPH, PotassiumChannel, Potassium Channel

Compound Identifiers

PubChem CID

1989