Cart summary

You have no items in your shopping cart.

A2M Antibody / Alpha-2-Macroglobulin

Catalog Number: orb2644553

DispatchUsually dispatched within 5-10 working days
$ 780.00
Catalog Numberorb2644553
CategoryAntibodies
DescriptionAlpha-2-Macroglobulin (A2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, it was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on A2M. This interaction induces a conformational change, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, A2M has been shown to function as a carrier protein and regulator of cytokines during inflammation.
ClonalityMonoclonal
Species/HostMouse
IsotypeMouse IgG1, kappa
ConjugationUnconjugated
ReactivityHuman
Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
PurityProtein G affinity chromatography
ImmunogenA portion of amino acids 604-748 from the human protein was used as the immunogen for the A2M antibody.
UniProt IDP01023
Tested applicationsIHC-P
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
Application notesOptimal dilution of the A2M antibody should be determined by the researcher.
Antibody TypePrimary Antibody
Clone NumberA2M/3623
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Hazard InformationThis A2M antibody is available for research use only.
NoteFor research use only
A2M Antibody / Alpha-2-Macroglobulin

IHC staining of FFPE human liver with A2M antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

A2M Antibody / Alpha-2-Macroglobulin

IHC staining of FFPE human liver with A2M antibody. HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

A2M Antibody / Alpha-2-Macroglobulin

Analysis of HuProt (TM) microarray containing more than 19000 full-length human proteins using A2M antibody. These results demonstrate the foremost specificity of the A2M/3623 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

A2M Antibody / Alpha-2-Macroglobulin

SDS-PAGE analysis of purified, BSA-free A2M antibody as confirmation of integrity and purity.

  • A2M Antibody / Alpha-2-Macroglobulin [orb699646]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    20 μg
  • A2M Antibody / Alpha-2-Macroglobulin [orb1825799]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg
  • A2M Antibody / Alpha-2-Macroglobulin [orb1825800]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    20 μg
  • A2M Antibody / Alpha-2-Macroglobulin [orb1825801]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg
  • A2M Antibody / Alpha-2-Macroglobulin [orb1825826]

    IHC-P

    Human

    Mouse

    Monoclonal

    Unconjugated

    100 μg