7,4'-Dimethoxy-3-hydroxyflavone

SKU: orb3135023

Description

7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. This compound inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. It disrupts PAR4-mediated aggregation and related signaling pathways, including NF-κB, Ca2+/protein kinase C (PKC), Akt, ERK, and p38. In a streptozotocin (STZ)-induced diabetic mouse model, 7,4'-Dimethoxy-3-hydroxyflavone inhibits vascular PAR4 expression, improves endothelial dysfunction, and reduces oxidative stress. Additionally, it prevents thrombosis in mice without affecting bleeding time.

Key Properties

• CAS Number: 13198-99-7
• MW: 298.29
• Formula: C₁₇H₁₄O₅
• SMILES: O=C1C(O)=C(OC2=CC(OC)=CC=C21)C=3C=CC(OC)=CC3
• Target: NF-κB,Akt,ROS,Protease-activated Receptor,p38 MAPK,Calcium Channel,PKC,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB,Akt,ROS,Protease-activated Receptor,p38 MAPK,Calcium Channel,PKC,ERK