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Catalog Number | orb758810 |
---|---|
Category | Antibodies |
Description | Rat monoclonal antibody to 4-1BBL |
Species/Host | Rat |
Clonality | Monoclonal |
Clone Number | AT113-2 |
Tested applications | Blocking, FC, WB |
Reactivity | Mouse |
Isotype | IgG1 |
Immunogen | This antibody was raised by immunising LOU rats with soluble recombinant 4-1BBL:Fc fusion protein. |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | 4-1BBL |
UniProt ID | P41274 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | CD137L; TNFSF9; 4-1BB ligand; 41BBL; CDw137L; homo Read more... |
Note | For research use only |
Application notes | This antibody has been used in various FACS analyses, for instance, to show that CD27:CD70 and 4-1BB:4-1BBL interactions are needed for dendritic cell-driven accumulation of antitumor cytotoxic T lymphocytes following anti-CD40 mAb treatment (French et al, 2007), to examine the underlying mechanisms of the differential T cell costimulation dependence in viral infections (Welten et al, 2015), and to explore the therapeutic benefit of using combinations of syngeneic tumor vaccines that express immune modulators (Manrique-Rincón et al, 2017). This antibody has been used as a blocking antibody, together with anti-CD70, anti-CD30L and anti-OX40L antibodies, to evaluate OX40 ligand and CD70 in the promotion of CD4+ T cell responses (Kurche et al, 2010). Furthermore, this anti-4-1BBL antibody has been used alongside the anti-CD70, anti-CD27, anti-CD40 antibodies in a BCL1-bearing mouse model to evaluate the theurapeutic potency of various combined immmunotherapies against lymphoma (French et al, 2007). |
Expiration Date | 12 months from date of receipt. |
ELISA, IF, IHC | |
Human | |
Rabbit | |
Polyclonal | |
Unconjugated |
IF, WB | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
ELISA, FA, FACS, Kinetics | |
Human | |
Monoclonal | |
Unconjugated |
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