3,4-Dibromo-Mal-PEG2-N-Boc

SKU: orb1989619

Description

3,4-Dibromo-Mal-PEG2-N-Boc is a bifunctional linker used to construct PROTAC molecules for targeted protein degradation research. Its design facilitates the assembly of heterobifunctional degraders, enabling the study of ubiquitin-proteasome system-mediated degradation in both cellular and biochemical assays.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1807537-43-4
• MW: 486.15
• Purity: 99.24% (May vary between batches)
• Formula: C₁₅H₂₂Br₂N₂O₆
• SMILES: O=C(OC(C)(C)C)NCCOCCOCCN1C(=O)C(Br)=C(Br)C1=O
• Target: PROTAC Linker
• Solubility: DMSO:80 mg/mL (164.56 mM)

Bioactivity

• In Vitro:
  PROTACs are compounds that consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade the target proteins.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Alkyl/ether, 3,4-Dibromo-Mal-PEG-2-N-Boc, 3,4-Dibromo-Mal-PEG2-N-Boc, 3,4DibromoMalPEG2NBoc, 3,4 Dibromo Mal PEG2 N Boc, PEGs

Compound Identifiers

PubChem CID

77078278