2-Chloroadenosine

SKU: orb1299551

Description

2-Chloroadenosine

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 146-77-0
• MW: 301.7
• Purity: >95%
• Formula: C₁₀H₁₂ClN₅O₄
• SMILES: NC1=C2N=CN(C3OC(CO)C(O)C3O)C2=NC(Cl)=N1
• Target: GPCR
• Solubility: Soluble in DMSO (up to 30 mg/ml) or in Water (up to 7 mg/ml).

Bioactivity

• Target IC50:
  A1:300nM(Ki) |A3:1,900 nM(Ki)|A2A:80nM(Ki)
• In Vivo:
  2-Chloroadenosine(CADO) has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures. It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-CAdo; 2-CADO; 2-Cl Ado

Compound Identifiers

PubChem CID

235481