2-Chloroadenosine

SKU: orb1299551

Description

2-Chloroadenosine

Research Area

Cell Biology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 146-77-0
• MW: 301.69
• Purity: 99.24%
• Formula: C₁₀H₁₂ClN₅O₄
• SMILES: NC1=C2N=CN(C3OC(CO)C(O)C3O)C2=NC(Cl)=N1
• Target: Apoptosis,Nucleoside Antimetabolite/Analog,Adenosine Receptor
• Solubility: DMSO:45 mg/mL (149.16 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.63 mM)

Bioactivity

• Target IC50:
  A1:300nM(Ki) |A3:1,900 nM(Ki)|A2A:80nM(Ki)
• In Vivo:
  2-Chloroadenosine(CADO) has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures. It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

analogue, Adenosine Receptor, Adenosine receptor, AdenosineReceptor, 2Chloroadenosine, 2-Chloroadenosine, 2 Chloroadenosine, cell, human, erythrocytes,uridine, Inhibitor, inhibit, ischaemic, influx,nitrobenzylthioinosine, loss, transported, permeant

Compound Identifiers

PubChem CID

235481