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Catalog Number | orb1825198 |
---|---|
Category | Antibodies |
Description | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. The YWHAE gene which encodes 14-3-3E has also been identified as a possible susceptibility gene for schizophrenia. |
Species/Host | Mouse |
Clonality | Recombinant |
Clone Number | rYWHAE/8860 |
Tested applications | IHC-P |
Predicted Reactivity | Rat |
Reactivity | Human |
Isotype | Mouse IgG1, kappa |
Immunogen | Recombinant human full-length protein was used as the immunogen for the recombinant YWHAE antibody. |
Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
Hazard Information | This recombinant YWHAE antibody is available for research use only. |
UniProt ID | P62258 |
Storage | Aliquot the recombinant YWHAE antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human prostate carcinoma tissue with recombinant YWHAE antibody (clone rYWHAE/8860). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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