MMI 0100

• Catalog Number: orb1736863
• Category: Proteins
• Description: MAPK-activated protein kinase II inhibitor; Cell penetrating peptides.
• CAS Number: 1039342-24-9
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2283.64 Da
• Formula: C₉₈H₁₇₁N₃₇O₂₆
• Structure: H-Tyr-Ala-Arg-Ala-Ala-Ala-Arg-Gln-Ala-Arg-Ala-Lys-Ala-Leu-Ala-Arg-Gln-Leu-Gly-Val-Ala-Ala-OH
• Protein Sequence: YARAAARQARAKALARQLGVAA
• Storage: Store dry, frozen and in the dark
• Alternative names: YARA, MMI-0100
• Background: MMI 0100 is a cell-permeable peptide inhibitor of mitogen activated protein kinase-activated protein kinase 2 (MK2). YARAAARQARA, also known as PDT-4, is the fragment that confers cell permeability and it also provides more selectivity to inhibit MK2. MK2 is activated by the MAP kinases p38α and p38β, which in turn are activated by environmental stresses including heat shock, hypoosmolarity, hypoxia and inflammatory cytokines, and inhibition of MK2 may be beneficial in multiple human diseases including neuroinflammation, cancer, neural ischemia, rheumatoid arthritis, and inflammatory bowel disease. Neuroinflammation is considered a causative agent in Alzheimer's disease (AD) and accordingly, in mouse models of AD, MMI 0100 ameliorates the memory deficit induced by Aβ1ˆ’42 or lipopolysaccharide in novel object and location tasks. Similarly, in models of acute colitis induced by dextran sodium sulfate (DSS), MMI 0100 attenuates DSS-induced body weight loss, colon length shortening, and colonic pathological injury.
• Note: For research use only
• Expiration Date: 6 months from date of receipt.

Structure for MMI 0100