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Caspase 8 antibody

Size Price Availability Qty
5 μg (Trial Size)
Available now for quick dispatch
20 μg (Trial Size)
Available now for quick dispatch
100 μg
Usually dispatched within 5-10 working days
200 μg
Usually dispatched within 5-10 working days
Shipping charges : Freight/Packing: $34

Rabbit polyclonal antibody to caspase 8 also known as CASP-8 and CAP4 whose expression can be detected in various tissues but is highly expressive in the thymus and spleen. It is found in the CD95 death-inducing signaling complex. Its binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases.

Product Information

PubMed 26332509
Category Primary antibodies
Product name Caspase 8 antibody
Catalog Number orb10241
Host Rabbit
Clonality Polyclonal
Tested applications IHC-P, IF/ICC, FACS, P-ELISA
Dilution range P-ELISA: 1:500-1000, IHC-P: 1:400-800μg/Test, IF/ICC: 1:100-500
Concentration - 5 μg (in 100 μl): 0.05 mg/ml
- 20 μg (in 100 μl): 0.2 mg/ml
- 100 μg (in 200 μl): 0.5 mg/ml
- 200 μg (in 400 μl): 0.5 mg/ml
Reacts with Human, Mouse, Rat
Predicted reactivity Cow, Pig, Dog, Chicken
UniProt ID Q14790 (Human); O89110 (Mouse); Q9JHX4 (Rat)
NCBI NP_001073593.11; NM_001080124.11
Entrez 841
Conjugation Unconjugated
Immunogen KLH conjugated synthetic peptide derived between 421-472 amino acids of human Caspase 8
Purity Affinity purified by Protein A
MW 12/55 kDa
Isotype IgG
Form Liquid: 0.01M TBS (pH7.4), 0.5% BSA, 0.015% ProClin™ 300 and 25% glycerol
References Differential short-term regional effects of early high dose erythropoietin on white matter in preterm lambs after mechanical ventilation.
Storage Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
Note For research use only.
Target Caspase 8
Alternative names
Anti-Caspase-8 antibody, anti-CASP-8 antibody, anti-ICE-like apoptotic protease 5 antibody, anti-MACH antibody, anti-FADD-homologous anti-FADD-like ICE antibody, anti-FLICE antibody, anti-Apoptotic cysteine protease antibody, anti-Apoptotic protease Mch-5 antibody, anti-CAP4 antibody, anti-Caspase-8 subunit p18 antibody, anti-Caspase-8 subunit p1 antibody

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Click image to enlarge
Immunohistochemical analysis of paraffin embedded human rectal cancer tissue using Caspase 8 antibody
IHC-P of human rectal cancer tissue (Caspase 8 antibody at 1:200)
Immunohistrochemical analysis of formalin fixed and paraffin embedded human rectal carcinoma tissue using Caspase 8 antibody
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