INVA8001

SKU: orb3174450

Description

INVA8001 is a highly selective and orally active chymase inhibitor, with IC50 values of 0.02 μM for human chymase and 0.03 μM for mouse mast cell protease 4 (mMCP-4). It exhibits IC50 values of 3.4 μM for bovine α-chymotrypsin and 32.1 μM for human cathepsin G, demonstrating over 1000-fold selectivity against other related serine proteases. In a mouse model of primary sclerosing cholangitis (PSC), INVA8001 inhibits mast cell activity, improves biliary pathology, alleviates cholestasis, and displays anti-inflammatory and anti-fibrotic properties.

Key Properties

• CAS Number: 1312993-34-2
• MW: 620.1
• Formula: C₂₉H₃₈ClN₅O₈
• SMILES: C(C)(O)=O.C(C1=C(OC)C=CC(Cl)=C1)[C@@H]2C(=O)N(C(N[C@H](CCC)C3=CC(N)=C(C(O)=O)C=C3)=O)C\C(=N\OCC)\NC2
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Others