BI-9740

SKU: orb3173864

Description

BI-9740 is an orally active, selective inhibitor of cathepsin C (CatC), displaying an IC50 of 0.6 nM in mice and 2.6 nM in rats. It inhibits the production of active neutrophil elastase and also reduces neutrophil elastase and cathepsin G activity in rat bone marrow, thereby alleviating pathological damage in heart transplants, shortening recovery time, and enhancing left ventricular function. BI-9740 is applicable for research related to organ transplantation.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1628596-25-7
• MW: 432.5
• Formula: C₂₅H₂₅FN₄O₂
• SMILES: CN1C=2C(=CC=C(C2)C3=CC(F)=C(C[C@H](NC(=O)[C@@H]4[C@@]5(C[C@](N4)(CC5)[H])[H])C#N)C=C3)CC1=O
• Target: Cysteine Protease,Serine Protease

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cysteine Protease,Serine Protease