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Methylation Antibodies
Histone methylation, methyl-lysine and methylation-state-specific antibodies.
BrowsePTM Antibodies
Explore Biorbyt antibodies for studying protein post-translational modifications (PTMs), including methylation, acetylation, ubiquitination, SUMOylation and other modification-specific targets.
Find pan-modification, site-specific and linkage-specific antibodies for protein regulation, epigenetics and cell signalling research.
Browse PTM Antibodies
Start with the protein modification you need to detect.
Ubiquitination Antibodies
Pan-ubiquitin and linkage-specific antibodies, including K48- and K63-linked ubiquitin.
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Looking for Phospho-Specific Antibodies?
Phosphorylation is a major post-translational modification and has a dedicated Biorbyt antibody collection.
Additional & Specialized PTM Antibodies
Explore additional modification classes for specialized protein and epigenetic research.
Citrullination
Citrullinated proteins and histone sites
Lactylation
Lactyl-lysine and site-specific lactylation
Crotonylation
Crotonyl-lysine and histone crotonylation
Succinylation
Succinyl-lysine modification antibodies
NEDD8 / NEDDylation Research
NEDD8 pathway research antibodies
Protein Nitration
Nitrotyrosine and nitrated protein detection
What Are PTM Antibodies?
Post-translational modifications are covalent changes that can regulate protein activity, localisation, interactions, stability and turnover. PTM-specific antibodies enable researchers to detect defined protein modification states.
Depending on the experiment, an antibody may recognise a broad modification such as acetyl-lysine, a defined modified residue such as H3K27ac, or a specific ubiquitin linkage such as K48 or K63.
How to Choose a PTM Antibody
PTM antibody selection depends on the exact modification state, specificity and validation required for your experiment.
1
Define the modification
Identify the PTM you need to measure, such as methylation, acetylation, ubiquitination or SUMOylation. For methylation, also consider the required modification state such as me1, me2 or me3.
2
Choose the right specificity
Decide whether you need a pan-modification antibody, a defined residue-specific antibody, or a linkage-specific reagent such as K48- or K63-linked ubiquitin.
3
Review validation data
Prioritise antibodies validated for your intended application and species. Review available experimental images and specificity information before selection.
4
Plan the appropriate control
Where relevant, compare the PTM-specific signal with the corresponding total target to distinguish changes in modification state from changes in protein abundance.
Featured PTM Antibodies
Explore representative Biorbyt antibodies across major and specialized PTM classes, selected for application coverage and available validation data.
| PTM | Featured Antibody | Tested Applications | Reactivity | SKU |
|---|---|---|---|---|
| Methylation | Histone H3 (TriMethyl-K4) Rabbit Polyclonal Antibody | ChIP, IF, IHC, IP, WB | Human, Mouse, Rat | orb412092 |
| Acetylation | Acetyl-Histone H3-K27 Polyclonal Antibody | ChIP, IF, IHC, IP, WB | Human, Mouse, Rat, Other | orb648591 |
| Ubiquitination | K63-linkage Specific Ubiquitin Recombinant Rabbit Monoclonal Antibody | FC, ICC, IF, IHC-Fr, IHC-P, WB | Human, Mouse, Rat | orb2561105 |
| SUMOylation | PML Sumoylation Site Antibody | FC, IF, IHC-P, WB | Human | orb33903 |
| Citrullination | Histone H3 Citrullination Arg2+Arg8+Arg17 Rabbit Monoclonal Antibody | IF, IHC, IP, WB | Human, Mouse, Rat | orb3227160 |
| Crotonylation | Crotonyl-HIST1H2BC (K12) Antibody | ChIP, ELISA, IF, IP, WB | Human | orb516361 |
Need help selecting a PTM antibody?
Our scientific support team can help compare modification sites, specificity, species reactivity and validation data.