Picroside I

SKU: orb1305018

Description

Picroside I is a hepatoprotective small molecule with reported antimicrobial activity against hepatitis B. Its antioxidant and anti-inflammatory properties, along with its ability to suppress collagenases and gelatinases, make it a candidate for cancer and neuroscience research, as demonstrated in studies on neurite outgrowth in PC12D cells.

Research Area

Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 27409-30-9
• MW: 492.47
• Purity: 99.70%
• Formula: C₂₄H₂₈O₁₁
• SMILES: OC[C@]12O[C@H]1[C@@H](O)[C@@H]1C=CO[C@@H](O[C@@H]3O[C@H](COC(=O)\C=C\c4ccccc4)[C@@H](O)[C@H](O)[C@H]3O)[C@H]21
• Target: MMP,STAT
• Solubility: DMSO:55 mg/mL (111.68 mM);Ethanol:10 mg/mL (20.31 mM);H2O:10 mg/mL (20.31 mM)

Bioactivity

• In Vitro:
  Picroside I and Picroside II caused a concentration-dependent (> 0.1 microM) enhancement of basic fibroblast growth factor (bFGF, 2 ng/ml)-, staurosporine (10 nM)- and dibutyryl cyclic AMP (dbcAMP, 0.3 mM)-induced neurite outgrowth from PC12D cells. Furthermore, picrosides-induced enhancements of the bFGF-action were markedly inhibited by GF109203X (0.1 microM), a protein kinase C inhibitor. The expression of phosphorylated MAP kinase was markedly increased by bFGF (2 ng/ml) and dbcAMP (0.3 mM), whereas that was not enhanced by staurosporine (10 nM). Picrosides had no effect on the phosphorylation of MAP kinase induced by bFGF or dbcAMP and also unaffected it in the presence of staurosporine. These results suggest that Picroside I and Picroside II enhance bFGF-, staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying a down-stream step of MAP kinase in the intracellular MAP kinase-dependent signaling pathway.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

STAT, Picroside I, MMP, inhibit, Inhibitor, 6'-Cinnamoylcatalpol

Compound Identifiers

PubChem CID

6440892