Picolinamide

SKU: orb1300326

Description

Picolinamide (Picolinoylamide) is a potent inhibitor of poly(ADP-ribose) synthetase (PARP), as demonstrated in studies using nuclei from rat pancreatic islet cells. This small molecule is a valuable research tool for investigating PARP-mediated processes in diabetes research, cellular stress response, and in vitro models of islet cell function.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1452-77-3
• MW: 122.12
• Purity: 99.92% (May vary between batches)
• Formula: C₆H₆N₂O
• SMILES: NC(=O)C1=NC=CC=C1
• Target: PARP
• Solubility: DMSO:45 mg/mL (368.49 mM);H2O:22 mg/mL (180.15 mM);Ethanol:23 mg/mL (188.34 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (16.38 mM)

Bioactivity

• Target IC50:
  PARP:95 μM
• In Vivo:
  Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment.
• In Vitro:
  In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-Carbamoylpyridine, 2-Pyridinecarboxamide, 2-Picolinamide, PARP, Picolinoylamide, Picolinamide

Compound Identifiers

PubChem CID

15070