Picolinamide

SKU: orb1222689

Description

Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

Key Properties

• CAS Number: 1452-77-3
• MW: 122.12
• Purity: >98% (HPLC)
• Formula: C₆H₆N₂O
• SMILES: C1=CC=NC(=C1)C(=O)N
• Target: PARP
• Solubility: In Vitro: H2O : 100 mg/mL (818.87 mM)

Bioactivity

• In Vivo:
  Picolinamide (4 mmol/kg, i.p. , rats) inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. Picolinamide (250 mg/kg, i.p. , rats) enhances the tumorigenic effect of Streptozotocin and Alloxan on islet B-cells. Animal model: Rats. Dosage: 4 mmol/kg. Administration: Intraperitoneal injection (i.p.). Result: Increased renal cortical NAD content (1.5 fold).
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• In Vitro:
  Picolinamide (10 μM-1 mM) inhibits Poly(ADP-ribose) synthetase activity. Picolinamide (2 mM) protects against streptozotocin-induced depression of proinsulin synthesis in isolated pancreatic islets of rats.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PARP