PHT-427

SKU: orb1305508

Description

PHT-427

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1191951-57-1
• MW: 409.61
• Purity: 97.54% (May vary between batches)
• Formula: C₂₀H₃₁N₃O₂S₂
• SMILES: CCCCCCCCCCCCc1ccc(cc1)S(=O)(=O)Nc1nncs1
• Target: Akt,PDK,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.88 mM);DMSO:45 mg/mL (109.86 mM)

Bioactivity

• Target IC50:
  PDK1:5.2 μM(Ki)|Akt:2.7 μM(Ki)
• In Vivo:
  PHT-427 had an antiproliferative effect on Panc-1 cells (IC50: 65 μM). In PC-3 prostate cancer cells, PHT-427 (10 μM) significantly decreased p-Ser241-PDPK1 and p-Thr308-Akt, indicating that PHT-427 could inhibit Akt and PDKP1. PHT-427 also inhibited the translocation of the PH domains of Akt and PDKP1 in the plasma membrane. PHT-427 induced apoptosis and inhibited AKT phosphorylation, mainly at residue Ser473 and less at residue Thr308 (IC50: 6.3 μM), with no effect on all AKT protein expression.
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• In Vitro:
  PHT-427 had an antiproliferative effect on Panc-1 cells (IC50: 65 μM). In PC-3 prostate cancer cells, PHT-427 (10 μM) significantly decreased p-Ser241-PDPK1 and p-Thr308-Akt, indicating that PHT-427 could inhibit Akt and PDKP1. PHT-427 also inhibited the translocation of the PH domains of Akt and PDKP1 in the plasma membrane. PHT-427 induced apoptosis and inhibited AKT phosphorylation, mainly at residue Ser473 and less at residue Thr308 (IC50: 6.3 μM), with no effect on all AKT protein expression.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, CS 0223, CS0223, CS-0223, Akt, Apoptosis, PHT 427, PHT427, PHT-427, PKB, PDK1, Protein kinase B

Compound Identifiers

PubChem CID

44240850