Pantoprazole

SKU: orb1300338

Description

Pantoprazole (BY1023) is a proton pump inhibitor employed in research to study gastric acid suppression. It is widely used in both in vitro enzymatic assays and in vivo models to investigate GERD, peptic ulcers, and related gastrointestinal disorders.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 102625-70-7
• MW: 383.37
• Purity: 99.28%
• Formula: C₁₆H₁₅F₂N₃O₄S
• SMILES: S(CC1=C(OC)C(OC)=CC=N1)(=O)C=2NC=3C(N2)=CC(OC(F)F)=CC3
• Target: Apoptosis,Autophagy,Antibacterial,Proton pump
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.22 mM);Ethanol:71 mg/mL (185.2 mM);DMSO:250 mg/mL (652.11 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  PPZ(Pantoprazole) inhibits the proliferation of tumor cells, induces apoptosis and downregulates the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase). Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells. Moreover, knockdown of TOPK in HCT 116 cells decreased their sensitivities to pantoprazole.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Proton Pump, Proton pump, Protonpump, PPI, release, SKF 96022, SKF96022, SKF-96022, stability, A431, Autophagy, anti-ulcer, anti-secretory, Apoptosis, BY 1023, BY1023, BY-1023, Doxorubicin, H+/K+-ATPase, exosome, MCF-7, inhibit, Inhibitor, orally, Pantoprazole

Compound Identifiers

PubChem CID

4679