Paeoniflorin

SKU: orb1225578

Description

Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.(In Vitro):Paeoniflorin (80 μg/mL; 4-24 h) treatment can induce Hsp40 and Hsp27 as well as Hsp70.(In Vivo):Paeoniflorin (intradermal injection; 25 and 100mg/kg; once daily; 20 days) shows favorable effects on experimental arthritis.

Key Properties

• CAS Number: 23180-57-6
• MW: 480.46
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₈O₁₁
• SMILES: O[C@@H]([C@@H]([C@@H]([C@H](CO)O1)O)O)[C@H]1O[C@@]2(C3)C(C4)(C)OC5OC4(O)C3C25COC(C6=CC=CC=C6)=O
• Target: COX
• Solubility: DMSO: 96mg/ml (199.81 mM); Water: 96mg/ml (199.81 mM); Ethanol: 96mg/ml (199.81 mM)

Bioactivity

• In Vivo:
  Paeoniflorin (intradermal injection; 25 and 100 mg/kg; once daily; 20 days) shows favorable effects on experimental arthritis. Animal model: SD rats with collagen induced arthritis. Dosage: 25 and 100 mg/kg. Administration: Intradermal injection; 25 and 100 mg/kg; once daily; 20 days. Result: Decreased arthritis score, relieved ankle and paw swelling, improved spleen istopathology, decreased the levels of IgA, IgM, IgG and anti-CII antibody.
• In Vitro:
  Paeoniflorin (80 μg/mL; 4-24 h) treatment can induce Hsp40 and Hsp27 as well as Hsp70. Western blot analysis. Cell line: HeLa and IMR-32 cells. Concentration: 80 μg/mL. Incubation time: 4, 8, 12, 16, and 24 hours. Result: Promoted the phosphorylation of HSF1.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 178886

Quick Database Links

Gene Symbol

COX