Magnolol

SKU: orb1304635

Description

Magnolol is a bifunctional agonist of RXRα (EC50=10.4 µM) and PPARγ (EC50=17.7 µM) that also inhibits TNF-α-mediated NF-κB activation. This dual activity makes it a useful research tool for studying metabolic and inflammatory pathways in both cellular and animal models of disease.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 528-43-8
• MW: 266.33
• Purity: 100.00%
• Formula: C₁₈H₁₈O₂
• SMILES: OC=1C(=CC(CC=C)=CC1)C2=CC(CC=C)=CC=C2O
• Target: Retinoid Receptor,p53,Antibacterial,NF-κB,PPAR,Autophagy
• Solubility: DMSO:245 mg/mL (919.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.77 mM);Ethanol:49 mg/mL (183.98 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  PPARγ:17.7 μM (EC50)|RXRα:10.4 μM (EC50)
• In Vitro:
  Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Autophagy, 5,5'-Diallyl-2,2'-biphenyldiol, p53, NSC293099, NSC-293099, NFkB, NFκB, NF-kB, NF-κB, NSC 293099, inhibit, Magnolol, Inhibitor, PPARγ, PPAR, Peroxisome proliferator-activated receptors, RAR/RXR, RXRα, Retinoid X receptors, Retinoid Receptor, RetinoidReceptor, Retinoic acid receptors

Compound Identifiers

PubChem CID

72300