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Resiquimod
Catalog Number: orb1300307
| Catalog Number | orb1300307 |
|---|---|
| Category | Small Molecules |
| Description | Resiquimod |
| Purity | 99.78% |
| MW | 314.38 |
| Biological Activity | Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and activating TLR7 and 8 mainly on dendritic cells, macrophages, and B-lymphocytes. This induces the nuclear translocation of the transcription activator NF-kB as well as activation of other transcription factors. This may lead to an increase in mRNA levels and subsequent production of cytokines, especially interferon-alpha (INF-a) and other cytokines, thereby enhancing T-helper 1 (Th1) immune responses. In addition, topical application of resiquimod appears to activate Langerhans' cells, leading to an enhanced activation of T-lymphocytes. |
| CAS Number | [144875-48-9] |
| Formula | C17H22N4O2 |
| SMILES | CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O |
| Storage | -20°C |
| Note | For research use only |
Resiquimod [orb1222690]
> 98% (HPLC)
144875-48-9
314.4
C17H22N4O2
10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 g, 500 mg
