TAT-GluR6-9c

• Catalog Number: orb1736862
• Category: Proteins
• Description: GluR6-PSD95 interaction blocker; Cell penetrating peptides.
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2542.47 Da
• Formula: C₁₀₆H₁₉₁N₄₅O₂₆S
• Structure: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Leu-Pro-Gly-Lys-Glu-Thr-Met-Ala-OH
• Solubility (25°C): Soluble in saline
• Protein Sequence: YGRKKRRQRRRRLPGKETMA
• Storage: Store dry, frozen and in the dark
• Alternative names: Tat-GluR6-9c
• Background: TAT-GluR6-9c is a peptide derived from the nine C terminal residues of the kainate receptor subunit GluR6, linked to the cell penetrating sequence TAT. TAT-GluR6-9c is able to perturb the interaction of GluR6 with postsynaptic density protein 95 (PSD-95) and suppress the assembly of the GluR6-PSD-95-mixed lineage protein kinase 3 (MLK3) signalling module, causing inhibition of c-Jun N-terminal kinase (JNK) activation. JNK has an important role during global and focal cerebral ischemia/reperfusion and consistent with JNK inhibition, TAT-GluR6-9c pretreatment decreases neuronal death induced by kainate in vitro. In vivo, TAT-GluR6-9c protects against kainate-induced epileptic seizure and has a neuroprotective effect against ischaemic brain damage, significantly decreasing neuronal degeneration.
• Note: For research use only
• Expiration Date: 6 months from date of receipt.