Zotiraciclib citrate

• Catalog Number: orb2815085
• Category: Small Molecules
• Description: Zotiraciclib (also known as TG02 and SB1317) is an innovative small-molecule compound with potent inhibitory effects on CDK, JAK2, and FLT3. By inhibiting cyclin-dependent kinase 9 (CDK9) and depleting Myc, it serves as a treatment for cancers that can penetrate the blood-brain barrier. Zotiraciclib is one of the numerous CDK inhibitors under investigation; other compounds targeting CDK9, utilized for treating acute myeloid leukemia, include alvocidib and atuveciclib. Myc overexpression is a known factor in many cancers, with 80% of glioblastomas exhibiting this characteristic.
• MW: 564.59
• CAS Number: 1204918-73-9
• Formula: C₂₉H₃₂N₄O₈
• SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CN1C\C=C\CCOC2=CC(=CC=C2)C3=CC=NC(NC4=CC=CC(C1)=C4)=N3
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.