YJ1206

• Catalog Number: orb2695706
• Category: Small Molecules
• Description: YJ1206 is a highly potent and selective CDK12/13 PROTAC degrader (IC50 =12.55 nM) with the advantages of oral administration and low toxicity, which triggers gene-length-dependent transcription elongation defects, leading to DNA damage and cell-cycle arrest, and inhibits the proliferation of a subpopulation of prostate cancer cells. YJ1206 can synergize with AKT pathway inhibitors to effectively inhibit prostate cancer.
• Target: CDK,PROTACs
• Purity: 97.14%
• MW: 894.01
• CAS Number: 3053716-98-3
• Formula: C₄₉H₅₂FN₁₁O₅
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCC(CC4)N5CCN(CC5)C6=CC=C(N(C(NCC7=CC=CC=C7)=O)[C@@H]8CC[C@@H](NC9=NC%10=C(C=N9)C=CC=C%10)CC8)C=N6
• Storage: -20°C
• Research Area: Cell Biology, Pharmacology & Drug Discovery
• Note: For research use only
• Expiration Date: 12 months from date of receipt.