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SYVN1 (M) Antibody, Rabbit Polyclonal
Catalog Number: orb67250
| Catalog Number | orb67250 |
|---|---|
| Category | Antibodies |
| Description | Rabbit polyclonal to SYVN1.E3 ubiquitin-protein ligase synoviolin (SYVN1) is a multi-pass membrane protein that belongs to theHRD1 family. It acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically fromendoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting theirdegradation. SYVN1 protects cells from ER stress-induced apoptosis and protects neurons fromapoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promotingtheir degradation. It sequesters p53/TP53 in the cytoplasm and promotes its degradation, therebynegatively regulating its biological function in transcription, cell cycle regulation and apoptosis. |
| Species/Host | Rabbit |
| Clonality | Polyclonal |
| Tested applications | WB |
| Reactivity | Human |
| Immunogen | middle region of human SYVN1 |
| Dilution range | WB:1:500-1:2000 |
| Purity | Affinity purification |
| Conjugation | Unconjugated |
| MW | 68 |
| UniProt ID | Q86TM6 |
| Storage | -20°C |
| Buffer/Preservatives | 0.01% NaN3 |
| Alternative names | anti-SYVN1 antibody,anti-E3 ubiquitinprotein ligas Read more... |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Western blot analysis of total cell extracts from human Hela using SYVN1 antibody
