Sorafenib N-oxide

• Catalog Number: orb1693535
• Category: Small Molecules
• Description: Sorafenib N-oxide
• CAS Number: 583840-03-3
• Purity: 98%
• MW: 480.83
• SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1=O
• Formula: C₂₁H₁₆ClF₃N₄O₄
• Biological Activity: Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM). It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM). Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (Ki = 15 μM in human liver microsomes).
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.