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SIRP alpha V8 Protein, Human, Recombinant (His & Avi), Biotinylated
Catalog Number: orb1960275
| Catalog Number | orb1960275 |
|---|---|
| Category | Proteins |
| Description | Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V8 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 40.1 kDa and the accession number is ATD50864.1. |
| Tag | C-His-Avi |
| Purity | 98.00% |
| MW | 40.1 kDa (predicted). Due to glycosylation, the protein migrates to 52-68 kDa based on Tris-Bis PAGE result. |
| UniProt ID | ATD50864.1 |
| Expression System | HEK293 Cells |
| Biological Origin | Human |
| Biological Activity | Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V8 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 40.1 kDa and the accession number is ATD50864.1. |
| Expression Region | Glu31-Arg369(S44L, S50T, I52T, H54R, V57A) |
| Storage | -20°C |
| Note | For research use only |
| Application notes | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Expiration Date | 6 months from date of receipt. |
