Rhein-13C4

• Catalog Number: orb1693762
• Category: Small Molecules
• Description: Rhein-13C4
• CAS Number: 1189928-10-6
• Purity: 98%
• MW: 288.192
• SMILES: Oc1cccc2C(=O)c3[13cH]c([13cH][13c](O)c3C(=O)c12)[13C](O)=O
• Formula: C₁₅H₈O₆
• Biological Activity: Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically increasing TNF-α, IL-1β, and HMBG1 expression.2 Rhein shows efficacy against pancreatic fibrosis, chronic pancreatitis, and hyperglycemia-induced pancreatic β-cell apoptosis.3,4 It also inhibits angiogenesis of breast cancer cells under normoxic and hypoxic conditions.5
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.