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RecombinantFGF-18,Human
Catalog Number: orb1494884
| Catalog Number | orb1494884 |
|---|---|
| Category | Proteins |
| Description | Fibroblast Growth Factor-18 (FGF-18) is a heparin-binding growth factor that is a member of the FGF family. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. FGF-18 plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. FGF-18 is required for normal ossification and bone development. It can also stimulate hepatic and intestinal proliferation.Recombinant human Fibroblast Growth Factor-18 (rhFGF-18) produced in E.coli is a single non-glycosylated polypeptide chain containing 174 amino acids. A fully biologically active molecule, rhFGF-18 has a molecular mass of 20.3 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript. |
| Form/Appearance | Lyophilized after extensive dialysis against PBS. |
| Purity | > 95% by SDS-PAGE and HPLC analyses. |
| MW | 20.3 kDa, observed by reducing SDS-PAGE. |
| Protein Sequence | MAEENVDFR IHVENQTRAR DDVSRKQLRL YQLYSRTSGK HIQVLGRRIS ARGEDGDKYA QLLVETDTFG SQVRIKGKET EFYLCMNRKG KLVGKPDGTS KECVFIEKVL ENNYTALMSA KYSGWYVGFT KKGRPRKGPK TRENQQDVHF MKRYPKGQPE LQKPFKYTTV TKRSR |
| Source | Escherichia coli. |
| Biological Activity | ED50 1.0× 10ˆ5units/mg. |
| Endotoxins | < 0.2 EU/μg, determined by LAL method. |
| Storage | Lyophilized recombinant human Fibroblast Growth Factor-18 (rhFGF-18) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-18 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C. |
| Buffer/Preservatives | Lyophilized after extensive dialysis against PBS. |
| Alternative names | FGF18, Fibroblast Growth Factor-18, zFGF5, FGFI Read more... |
| Note | For research use only |
| Application notes | Reconstituted in ddH2O at 100 μg/ml. |
| Expiration Date | 6 months from date of receipt. |
