Rat BD-3 protein

• Catalog Number: orb107689
• Category: Proteins
• Description: Beta defensin-3, also known as BD-3 and DEFB-3, is a membrane active cationic peptide that functions in inflammation andinnate immune responses and coded by Defb 3 gene on chromosome 8 in mouse. There are at least 30 E-defensins which aredistinguished from F-defensins by the connectivity pattern of their three intramolecular disulfide bonds. BD3 is widely expressedamong epithelial tissues, notably by keratinocytes and airway epithelial cells. It is upregulated in response to proinflammatorycytokines, microbial and viral infections, and at the edges of skin wounds. BD3 induction in osteoarthritis chondrocytes promotesMMP1 and 13 productions and inhibits TIMP1 and 2 expressions.
• Target: BD-3
• Conjugation: Unconjugated
• Buffer/Preservatives: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Protein Sequence: KKVYNAVSCM TNGGICWLKC SGTFREIGSC GTRQLKCCKK K
• MW: 4.5 kDa
• Tested applications: HPLC, SDS-PAGE
• Biological Origin: E.coli
• Storage: Store at 4°C for up to two weeks. For long term storage, aliquot and store at -20°C, avoid freeze/thaw cycles.
• Alternative names: Rat Beta Defensin-3 protein
• Note: For research use only

SDS-PAGE analysis of Rat BD-3 protein