PV-1019

• Catalog Number: orb1744193
• Category: Small Molecules
• Description: PV-1019 (NSC 744039) is a potent and selective inhibitor of Chk2 with an IC50 of 24 nM, effectively inhibiting Topotecan-induced Chk2 autophosphorylation and suppressing IR-induced apoptosis [1].
• CAS Number: 1093793-05-5
• Purity: 98.00%
• MW: 379.37
• SMILES: N(=O)(=O)C1=C2C(C=C(C(NC3=CC=C(C(=NNC(=N)N)C)C=C3)=O)N2)=CC=C1
• Formula: C₁₈H₁₇N₇O₃
• Biological Activity: PV-1019 (NSC 744039) is a potent, selective inhibitor of Chk2, displaying an IC50 of 24 nM. It effectively inhibits Topotecan-induced Chk2 autophosphorylation and suppresses IR-induced apoptosis [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.