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ML-180
Catalog Number: orb1219596
| Catalog Number | orb1219596 |
|---|---|
| Category | Small Molecules |
| Description | ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 µM) .ML-180 (0.5-5 µM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 µM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling. |
| Target | orphan nuclear receptor NR5A2 |
| Purity | > 98% (HPLC) |
| MW | 388.89 |
| CAS Number | 863588-32-3 |
| Formula | C20H25ClN4O2 |
| Storage | Storage temperature: -20°C. Stability: ≥ 2 years |
| Note | For research use only |
ML-180 [orb1309410]
99.74%
[863588-32-3]
388.89
C20H25ClN4O2
100 mg, 50 mg, 25 mg, 10 mg, 5 mg, 2 mg, 1 mg, 1 ml x 10 mM (in DMSO)
