MI-2-2

• Catalog Number: orb692050
• Category: Small Molecules
• Description: MI-2-2 is a potent inhibitor of the menin-MLL interaction that binds to menin with low nanomolar affinity (Kd=22 nM); inhibits the interaction of menin with MLL-AF9 in HEK293 cells in a dose-dependent manner with 4-fold potentcy improvement over MI-2; suppresses growth of MLL-AF9–transformed BMCs; causes MV4:11 cells growth inhibition of with GI50 of 3 uM.
• CAS Number: [1454920-20-7]
• MW: 415.497
• SMILES: CC1(C)SC(N2CCN(C3C4C=C(CC(F)(F)F)SC=4N=CN=3)CC2)=NC1
• Formula: C₁₇H₂₀F₃N₅S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.