KKL-40

• Catalog Number: orb2944868
• Category: Small Molecules
• Description: KKL-40 is a small-molecule inhibitor that targets the trans-translation process, effectively suppressing methicillin-sensitive and resistant Staphylococcus aureus (S. aureus) and other Gram-positive pathogens, including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. It works in synergy with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not show synergistic effects with other antibiotics such as daptomycin, kanamycin, or erythromycin. KKL-40 inhibits trans-translation, an extreme form of recoding, while being non-toxic to HeLa cells.
• Target: Antibacterial,Antibiotic
• MW: 351.255
• CAS Number: 865285-47-8
• Formula: C₁₆H₉F₄N₃O₂
• SMILES: O=C(NC1=NN=C(O1)C=2C=CC(F)=CC2)C3=CC=CC(=C3)C(F)(F)F
• Storage: -20°C
• Research Area: Infectious Disease & Virology
• Note: For research use only
• Expiration Date: 12 months from date of receipt.