FL442

• Catalog Number: orb2665477
• Category: Small Molecules
• Description: FL442 is an Androgen Receptor (AR) modulator. This compound exhibits potent inhibitory effects in AR-dependent prostate cancer cells, showing similar suppression efficiency to the traditional antiandrogen drugs Bicalutamide and Enzalutamide. It also maintains antiandrogen activity against the Enzalutamide-resistant AR mutant F876L. The pharmacokinetic properties of FL442 in mice reveal a longer half-life (8 hours), excellent targeting (prostate tissue), and metabolic stability. Additionally, it is effective at inhibiting LNCaP tumor growth at low plasma concentrations (30 ng/mL).
• CAS Number: 1431166-12-9
• Purity: 98.00%
• MW: 294.27
• SMILES: N#CC=1C=CC(=CC1C(F)(F)F)C2=NOC3CCCCC23
• Formula: C₁₅H₁₃F₃N₂O
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.