Fasinumab

• Catalog Number: orb1290271
• Category: Antibodies
• Description: Fasinumab biosimilar
• Target: NGF/NGFB
• Clonality: Monoclonal
• Species/Host: Mouse
• Isotype: IgG4-kappa
• Conjugation: Unconjugated
• Reactivity: Human
• Buffer/Preservatives: PBS buffer pH 7.5
• Purity: > 95%
• Tested applications: ELISA
• Antibody Type: Biosimilar Antibody
• Source: CHO cells
• Biological Activity: Ro 08-2750 binds to the NGF dimer thereby probably inducing a change in its conformation such that NGF cannot bind to p75NTR anymore. Ro 08-2750 (10 nM) completely rescues cells from undergoing NGF-induced SK-N-MC 10^3 cells death.Ro 08-2750 (5-10 μM; 8 hours) increases differentiation and apoptosis in myeloid leukemia cells.Ro 08-2750 inhibits survival of human AML lines and patient cells.Ro 08-2750 inhibits MSI2 RNA-binding and alters MSI2 gene signature.
• CAS Number: 1190239-42-9
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Alternative names: REGN475, SAR164877
• Note: For research use only