D-159404

• Catalog Number: orb2815730
• Category: Small Molecules
• Description: D-159404, as an allosteric inhibitor, demonstrates superior inhibitory effects on the full-length PDE 4D3 compared to its truncated form and exhibits higher cellular activity. This sets it apart from competitive inhibitors like roflumilast and cilomilast. These findings indicate that D-159404 and related compounds may offer valuable insights into PDE 4 pharmacology and serve as strong candidates for further study on cAMP signaling's impact on disease treatment.
• MW: 384.83
• CAS Number: 1158221-32-9
• Formula: C₂₁H₁₈ClFN₂O₂
• SMILES: O=C(N)NC1=CC=C(C=C1)CC=2C=CC(OC)=C(C3=CC=CC(Cl)=C3)C2F
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.