CU-T12-9

• Catalog Number: orb1308425
• Category: Small Molecules
• Description: CU-T12-9
• Purity: 99.93%
• MW: 362.31
• Biological Activity: CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines, and enhancing TLR1 and TLR2 dimerization.CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS.
• CAS Number: 1821387-73-8
• Formula: C₁₇H₁₃F₃N₄O₂
• SMILES: CNc1ccc(cc1-n1cnc(c1)-c1ccc(cc1)C(F)(F)F)[N+]([O-])=O
• Storage: -20°C
• Note: For research use only