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COG 133
Catalog Number: orb654723
| Catalog Number | orb654723 |
|---|---|
| Category | Small Molecules |
| Description | COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].Substantially reduces the symptoms of experimental autoimmune encephalomyelitis, a model of human multiple sclerosis, and suppresses inflammation, demyelination and infiltration of cells into the spinal cord. Also acts as a non-competitive antagonist at α7 nicotinic acetylcholine receptors (IC50 = 445 nM). |
| MW | 2283.78 |
| CAS Number | [514200-66-9] |
| Formula | C99H182F3N37O21 |
| SMILES | [Ac-LRVRLASHLRKLRKRLL-NH2] |
| Note | For research use only |
COG 133 Acetate [orb1306212]
99.73%
2229.76
C99H185N37O21
1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO)
