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Cevidoplenib
Catalog Number: orb746249
| Catalog Number | orb746249 |
|---|---|
| Category | Small Molecules |
| Description | Cevidoplenib (SKI-O-703) is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential anti-inflammatory and immunomodulating activities. Cevidoplenib is also the mesylate form of SKI-O-592. Cevidoplenib and SKI-O-592 inhibits BCR-mediated survival, proliferation, and differentiation of B cells. And SKI-O-592 potently inhibits multiple kinases with IC50s of 6.2 nM (Syk), 1.859 μM (Jak2), 5.807 μM (Jak3), 0.412 μM (RET), 0.687 μM (KOR), 1.783 μM (FLT3), 16.96 μM (FGFR1), 5.662 μM (FGFR3), and 0.709 μM (Pyk2), respectively. |
| MW | 473.526984453201 |
| CAS Number | [1703788-21-9] |
| Formula | C25H27N7O3 |
| SMILES | O=C(C1=CN(C)C2C=CC(=CC1=2)NC1N=CC=C(N=1)N1C=C(C(C)=N1)CN1C[C@@H](CO1)O)C1CC1 |
| Note | For research use only |
Cevidoplenib dimesylate hydrochloride [orb1297874]
97.52%
269062-93-3
1957.9
C90H132Cl5N27O12
200 mg, 1 ml x 10 mM (in DMSO), 100 mg, 50 mg, 25 mg, 10 mg, 5 mg, 1 mgCevidoplenib dimesylate [orb1303532]
96.16%
[2043659-93-2]
665.74
C27H35N7O9S2
50 mg, 25 mg, 10 mg, 5 mg, 1 mg, 1 ml x 10 mM (in DMSO)
