BBO-8520

• Catalog Number: orb2566870
• Category: Small Molecules
• Description: BBO-8520 is a first-in-class, direct dual inhibitor of both the active (ON) and inactive (OFF) conformational states of KRASG12C. BBO-8520 binds to the Switch-II/Helix3 pocket of KRASG12C, covalently modifying the target cysteine residue and thereby disabling effector binding in the ON state. BBO-8520 exhibits potent inhibition of KRAS signaling under growth factor-activated conditions, where existing OFF-only inhibitors demonstrate minimal activity. In vivo, BBO-8520 rapidly engages its target and suppresses signaling, resulting in durable tumor regression across multiple models, including those resistant to OFF-only KRASG12C inhibitors.
• Target: Kras,Ras
• Purity: 97.88%
• MW: 729.74
• CAS Number: 2893809-51-1
• Formula: C₃₅H₃₃F₆N₇O₂S
• SMILES: N#CC1=C(SC2=C(F)C=CC(=C12)C=3C(F)=C4N=C(N=C(C4=CC3C(F)(F)F)N5CC(N(C(=O)C=C)CC5C)C)OCC67N(CCC6)CC(F)C7)N
• Storage: -20°C
• Research Area: Pharmacology & Drug Discovery, Signal Transduction
• Note: For research use only
• Expiration Date: 12 months from date of receipt.