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Catalog Number | orb1301793 |
---|---|
Category | Small Molecules |
Description | ARV-825 |
CAS Number | 1818885-28-7 |
Purity | 97.54% |
MW | 923.43 |
SMILES | CC=1C2=C(N3C([C@H](CC(NC4=CC=C(OCCOCCOCCOCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)C=C4)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C |
Formula | C46H47ClN8O9S |
Biological Activity | ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |