TROP2 Antibody (MMAE)

• Catalog Number: orb1805430
• Category: Antibodies
• Description: Anti-TROP2 Reference Antibody is expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 146.06 kDa.
• Target: TROP2
• Clonality: Recombinant
• Conjugation: MMAE
• Reactivity: Human
• Concentration: Batch dependent
• Buffer/Preservatives: 100 mM Proline/Acetic acid 20mM Arginine pH 5.0
• Purity: >95%
• Purification: Protein A
• UniProt ID: P09758
• MW: 150 kDa
• Tested applications: ELISA, FA, FACS, In vivo
• Antibody Type: Recombinant Antibody
• Expression System: CHO
• Endotoxins: <0.001 EU/ug
• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Note: For research use only

Anti-TROP2 Reference Antibody (Sacituzumab-MMAE) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

The purity of Anti-TROP2 Reference Antibody (Sacituzumab-MMAE)is more than 95% ;determined by SEC-HPLC.

Sacituzumab-ADC inhibited the tumor growth of MDA-MB-231 on NSG mice. The result showed significant anti-tumor effects; with an tumor inhibition rate (TGI) of 80.0% at 5 mpk at D37.