Alofanib

• Catalog Number: orb1302071
• Category: Small Molecules
• Description: Alofanib
• CAS Number: 1612888-66-0
• Purity: 99.53%
• MW: 413.4
• SMILES: Cc1cc(c(NS(=O)(=O)c2cccc(c2)C(O)=O)cc1-c1cccnc1)[N+]([O-])=O
• Formula: C₁₉H₁₅N₃O₆S
• Biological Activity: Alofanib is a selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect on FGF2-induced phosphorylation of FRS2a in KATO III cells (IC50 < 10 nM). It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.