Afatinib oxalate

• Catalog Number: orb1685964
• Category: Small Molecules
• Description: Afatinib oxalate
• CAS Number: 1398312-64-5
• Purity: 98%
• MW: 575.97
• SMILES: OC(C(O)=O)=O.CN(C)C/C=C/C(NC1=CC(C(NC2=CC(Cl)=C(C=C2)F)=NC=N3)=C3C=C1O[C@H]4CCOC4)=O.OC(C(O)=O)=O
• Formula: C₂₆H₂₇ClFN₅O₇
• Biological Activity: Afatinib (BIBW 2992) oxalate is an irreversible, orally active bispecific inhibitor of the ErbB family (EGFR and HER2) that acts on EGFRwt (IC50: 0.5 nM), EGFRL858R (IC50: 0.4 nM), EGFRL858R/T790M ( IC50: 10 nM) and HER2 (IC50: 14 nM). Afatinib oxalate can be used to study esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.